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Cover image for product 0470723386 Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. Lene Jorgensen (Editor), Hanne Morck Nielson (Co-Editor). January 2010. Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites.

Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:

  • challenges in delivery of biopharmaceuticals
  • novel formulation approaches for peptide and protein injectables
  • novel non-injectable formulation approaches of peptides and proteins
  • chemical vectors for delivery of nucleic acid based drugs
  • viral technology for delivery of nucleic acids
  • the innate immune response, adjuvants and delivery systems
  • solid lipid nanoparticle based systems for delivery of biomacromolecule therapeutics
  • dendrimers in delivery of biopharmaceuticals
  • modification of peptides and proteins
  • nanocarriers for the delivery of peptides and proteins
  • polymer-based delivery systems for oral delivery of peptides and proteins
  • advanced pulmonary delivery of peptide/protein drugs using polymeric particles
  • polymer microparticles for nucleic acid delivery
  • pulmonary delivery of small interfering RNA for novel therapeutics
  • lipid-based formulations for siRNA delivery
  • cellular bioavailability of peptide nucleic acids (PNA) conjugated to cell penetrating peptides
  • DEAE-Dextran-MMA graft copolymer for non-viral delivery of DNA
  • liposomes in adjuvant systems for parenteral delivery of vaccines
  • influenza virosomes as delivery systems for antigens
  • GRAZAX: an oromucosal vaccine for treating immunotheraphy against grass pollen allergy
  • delivery technologies for biopharmaceuticals: a critical assessment
  • Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development. ISBN: 978-0-470-72338-8 Hardcover 442 pages. $175.00

    Cover image for product 047146743XLeung’s Encyclopedia of Common Natural Ingredients: Used in Food, Drugs and Cosmetics, 3rd Edition.  Ikhlas A. Khan, Ehab A. Abourashed . 2009. This new Third Edition of Leung's Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics arrives in the wake of the huge wave of interest in dietary supplements and herbal medicine resulting from both trends in health and the Dietary Supplement and Health Education Act of 1994 (DSHEA). This fully updated and revised text includes the most recent research findings on a wide variety of ingredients, giving readers a single source for understanding and working with natural ingredients. The Encyclopedia continues the successful format for entries listed in earlier editions (consisting of source, description, chemical composition, pharmacology, uses, commercial preparations, regulatory status, and references). The text also features an easily accessible alphabetical presentation of the entries according to common names, with the index cross-referencing entries according to scientific names.

    This Third Edition also features:

    ISBN: 978-0-471-46743-4. Hardcover. 810 pages. $135.00

    Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena. Masood N. Khan (Editor), John W. Findlay (Editor). 2009. A consolidated and comprehensive reference on ligand-binding assays. Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field.

    Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include:

  • A general discussion of challenges and proven approaches in the development of ligand-binding assays
  • More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline
  • A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules
  • A practical approach to "fit-for-purpose" validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies
  • Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry. ISBN: 978-0-470-04138-3.Hardcover. 424 pages. $110.00

    Cover image for product 0470096039Dynamic Combinatorial Chemistry : In Drug Discovery, Bioorganic Chemistry, and Materials Science.  Benjamin L. Miller (Editor). Due December 2009. Effective techniques for applying Dynamic Combinatorial Chemistry. In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.

    Chapters cover:

    A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials. ISBN: 978-0-470-09603-1. Hardcover. 288 pages. $79.95.

    Cover image for product 0470319615Peptide and Protein Design for Biopharmaceutical Applications. Knud Jensen (Editor). 2009. Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include:

    Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry. ISBN: 978-0-470-31961-1. Hardcover. 306 pages. $155.00

    Compatibility of Pharmaceutical Solutions and Contact Materials: Safety Assessments of Extractables and Leachables for Pharmaceutical Products. Dennis Jenke. 2009. Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers. Compatibility of Pharmaceutical Products and Contact Materials helps pharmaceutical, toxicology, analytical, and regulatory affairs professionals assess the safety of leachable and extractable chemicals associated with drug product packaging, manufacturing systems, and devices. The most comprehensive resource available, its coverage includes the strategies, tactics, and regulatory requirements for performing safety assessments, along with the means for interpreting results. Additionally, the book's appendix provides a database, including CAS registry numbers, chemical formulas and molecular weights of extractable/leachable substances that have been reported in the chemical literature. Detailing the interconnected roles played by analytical chemistry, biological science, toxicology, and regulatory science, Compatibility of Pharmaceutical Products and Contact Materials supplies a much-needed, comprehensive resource to all those in pharmaceutical product or medical device development. ISBN: 978-0-470-28176-5. 379 pp. $110.00

    Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery.  Konstantin V. Balakin, Sean Ekins (Series Editor). due December 2009.  Extracting and applying knowledge from chemical, biological, and clinical data is one of the biggest problems for the pharmaceutical industry. Focusing on diverse data mining approaches for drug discovery, including chemogenomics, toxicogenomics, and individual drug response prediction, Pharmaceutical Data Mining links theory to applications to illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development. The book is of vital interest to pharmaceutical scientists, principal investigators and scientists, research directors, industrial and academic research libraries, and graduate students. ISBN: 978-0-470-19608-3 Hardcover 544 pages. US $125.00

    The Textbook of Pharmaceutical Medicine, 6th Edition. John P. Griffin (Editor). due December 2009. The Textbook of Pharmaceutical Medicine is a standard reference for all those working in pharmaceutical medicine and the recognised text for the UK Faculty of Pharmaceutical Medicine Diploma. This is a comprehensive volume covering the processes by which medicines are developed, tested and approved. Regulations for drug development in the UK, EU, USA, Australia and Japan are discussed, providing relevant information for drug approval in the main continents where new drugs are developed. The chapters are written by leading academics, medical directors and lawyers, providing authoritative and in-depth information for trainees on the Faculty course, and for physicians working in the pharmaceutical industry. As well as thorough updating of the regulatory chapters, the 6th edition includes chapters on these vital new areas: Paediatric regulation; Ethics; Due diligence and the pharmaceutical physician. ISBN: 978-1-4051-8035-1. Hardcover. 776 pages,  $259.95

    Pharmaceutical Bioassays: Methods and Applications. Shiqi Peng, Ming Zhao. November 2009. The definitive compendium of bioassay procedures and applications. A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students.

    Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which:

     ISBN: 978-0-470-22760-2.  Hardcover  480 pages. $125.00

    Microarray Innovations: Technology and Experimentation. Gary Hardiman. Series: Drug Discovery Series.  April 2009.